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Tumor necrosis factor‐alpha (TNF‐α) is a major inflammatory cytokine that induces interleukin (IL)‐8 production. Although some studies have reported the involvement of the p38 MAPK signaling pathway in TNF‐α‐induced IL‐8 production, its specific regulatory mechanisms in gingival epithelial cells (GECs) are still poorly understood. In the present study, Ca9‐22 cells were used as representative GECs...